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Duke Nukem: Chain Reaction System Requirements

Frontline Studios Game page

We have no record of a PC version of Duke Nukem: Chain Reaction, so there are no PC system requirements to show. It came out on Nintendo DS, PSP.

Running Duke Nukem: Chain Reaction on a computer

An emulator of the system the game came out on is another way to run it on a computer, and then the hardware it needs is the emulator's. You still need your own copy of the game.

melonDS

melonDS emulates Nintendo DS.

Supported systems

OS
Windows (x64, ARM64), Linux (x64, ARM64), macOS (Universal), FreeBSD, NetBSD and OpenBSD (x64)

Source: https://melonds.kuribo64.net/downloads.php, read on 2026-09-12.

PPSSPP

PPSSPP emulates PSP.

Supported systems

OS
Windows, Linux, macOS, Android, iOS
Graphics
Direct3D 11, Vulkan or OpenGL

Source: https://github.com/hrydgard/ppsspp, read on 2026-09-08.

Games of the same series that run on PC

Where Duke Nukem: Chain Reaction can be played

Platforms: Nintendo DS, PSP.

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