Spider-Man: Return of the Sinister Six has never been released for PC, so it has no PC system requirements. It came out on NES, Game Gear, SEGA Master System. Released in 1992.
Running Spider-Man: Return of the Sinister Six on a computer
There is no emulator for NES, Game Gear, SEGA Master System that this site will point you at.
Games of the same series that run on PC
Spider-Man: Homecoming - Virtual Reality Experience
The Amazing Spider-Man 2
The Amazing Spider-Man
Spider-Man: Shattered Dimensions
Spider-Man: Web of Shadows
Spider-Man: Friend or Foe
Where Spider-Man: Return of the Sinister Six can be played
Platforms: NES, Game Gear, SEGA Master System.
