Seasonal League of Legends Brazilian region’s second split for 2021 was organized by Riot Games in sponsorship with Gillette, Red Bull Brasil, Mastercard and KitKat. The online event went on from  2021-06-05 to 2021-09-04. There were 10 participating teams in the Second Split of 2021, in chase of the 40,000 USD prize pool ,as well as a slot to qualify for Worlds 2021.

The format was divided into group and playoffs stages. The first one had a double round robin format and all matches were in best-of-1. Only the top 6 were to qualify for the playoffs. The latter had best-of-5 maps and single elimination format. The winner was RED Canids, who got 13,500 USD from the prize cash.